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		<title>Answer to question of the day &#8211; symmetrical arthritis</title>
		<link>http://medicaleducator.co.uk/answer-to-question-of-the-day-symmetrical-arthritis.html</link>
		<comments>http://medicaleducator.co.uk/answer-to-question-of-the-day-symmetrical-arthritis.html#comments</comments>
		<pubDate>Tue, 09 Jun 2009 19:36:29 +0000</pubDate>
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				<category><![CDATA[Medical Education]]></category>
		<category><![CDATA[Medical finals]]></category>
		<category><![CDATA[exam MCQ]]></category>
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		<description><![CDATA[The answer is&#8230;. b. Rheumatoid arthritis
Symmetrical disease?
Erosions?
This is classical of RA X-ray changes that include
1. Erosions
2. Reduced joint space
3. Peri-articular osteoporosis
4. Nodules
So from the initial history of disease [small joints, both hands], the likely diagnoses would be

 RA
PsA
(less likely) gout.

Erosive changes are not specific to RA however but the findings were symmetrical

 both gout and [...]]]></description>
			<content:encoded><![CDATA[<p>The answer is&#8230;. <strong>b. Rheumatoid arthritis</strong></p>
<p>Symmetrical disease?<br />
Erosions?<br />
This is classical of RA X-ray changes that include</p>
<p>1. Erosions<br />
2. Reduced joint space<br />
3. Peri-articular osteoporosis<br />
4. Nodules</p>
<p>So from the initial history of disease [small joints, both hands], the likely diagnoses would be</p>
<ul>
<li> RA</li>
<li>PsA</li>
<li>(less likely) gout.</li>
</ul>
<p>Erosive changes are not specific to RA however but the findings were symmetrical</p>
<ul>
<li> both gout and PsA tend to be asymmetrical</li>
</ul>
<p>Don&#8217;t be put off by the fact he&#8217;s male, although RA is roughly 3x commoner in women. You dont get a mention of which joints are affected here: RA has a penchant for the wrists and MCP joints. Erosions of the ulnar styloid are very common.</p>
<p>Common x-ray changes of the different arthritides are shown below:</p>
<p><strong>Non Inflammatory</strong></p>
<p><em>Primary OA: Asymmetrical</em></p>
<p>There are classically 4 signs of OA on an X-ray: Occurs in classic joints eight bearing e.g. Hips&amp; Knees. May not be symmetrical.</p>
<p>1. Subchondral bone sclerosis<br />
2. Cystic Change<br />
3. Osteophytes<br />
4. Reduced Joint Space</p>
<p><em>Charcot Joints:</em></p>
<p>1. Destruction of the joint<br />
2. Disorganisation (bones not arranged in the correct /usual arrangement through gross destruction e.g. cuniforms of the foot.<br />
3. Increased density (sclerosis)<br />
4. Debris (boney debris from a destroyed joint: often with well defined margins<br />
5. Dislocation</p>
<p><em>Secondary OA</em></p>
<p>As per primary OA but occurring in a joint that has been previously damaged from any other disease process (inflammatory disease etc)</p>
<p><strong>Inflammatory</strong></p>
<p><em>Gout: Asymmetrical</em></p>
<p>The classical signs of gout on an Xray are: Erosions with sclerotic margins. Asymmetrical.</p>
<p>1. A relatively preserved joint space<br />
2. Minimal periarticular osteoporosis<br />
3. Nodules (these are in fact tophi)</p>
<p><em>Psoriatic Arthritis: Asymmetrical</em></p>
<p>The X-ray Changes are similar to rheumatoid but they differ in their distribution, and the formation of pencil in cup deformities along with osteolysis.</p>
<p>1. Asymmetrical distribution of disease<br />
2. Often affects PIP and DIP joints<br />
3. relative absence of peri-articular osteoporosis<br />
4. Erosions seen at the distal interphalangeal joints joints<br />
5. Reduced joint space<br />
6. Pencil in cup deformity (arthritis mutilans with telescoping of the fingers)- this is a result of osteolysis<br />
7. Loss of the terminal tufts of the phalanges (acro-osteolysis)<br />
8. Sacroiliac and spondylitic changes (similar to those of Ank. Spond.)</p>
<p><em>Rheumatoid Arthritis: Symmetrical</em></p>
<p>1. Erosions<br />
2. Reduced joint space<br />
3. Periarticular osteoporosis<br />
4. Nodules</p>
<p><em>Septic Arthritis: Asymmetrical</em></p>
<p>1. Periarticular osteoporosis<br />
2. Loss of joint space<br />
3. Deformity/subluxation<br />
4. Erosions<br />
5. Effusion<br />
6. Usually just 1 joint</p>
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