An unusual cause of jaundice… (or is it?)

A 38 year old female is diagnosed with breast cancer and having had a lumpectomy proceeds to have 6 cycles of chemotherapy.

PMHx: Asthma, Previous Intravenous drug user

SHx: Current smoker

She does not attend for her pre op chemotherapy clinic appointment, but nevertheless goes on to have the chemotherapy.

6 weeks into her chemotherapy treatment she becomes jaundiced and has the blood tests taken

The problem has not arisen as a result of an adverse drug reaction.

What is the most likely underlying problem that has caused her to be jaundiced?

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