A 38 year old female is diagnosed with breast cancer and having had a lumpectomy proceeds to have 6 cycles of chemotherapy.
PMHx: Asthma, Previous Intravenous drug user
SHx: Current smoker
She does not attend for her pre op chemotherapy clinic appointment, but nevertheless goes on to have the chemotherapy.
6 weeks into her chemotherapy treatment she becomes jaundiced and has the blood tests taken
The problem has not arisen as a result of an adverse drug reaction.
What is the most likely underlying problem that has caused her to be jaundiced?