Clinical Pharmacology and Toxicology by Medical Educator : July 14, 2022July 14, 2022 Clinical Pharmacology and Toxicology What are the commoner side effects of the following drugs? Beta blockersDigoxinCalcium channel blockersSpirinolactoneStatinsCorticosteroids Show Answer Beta blockers block both beta 1 and beta 2 receptors so their side effects as well as acting on the heart are seen elsewhere e.g. in the form of bronchospasm, bradycardia etc. Digoxin toxicity can occur in patients on a stable dose of digoxin who develop another problem e.g. overdose/ acute renal impairment (part of digoxin is renally excreted). Calcium channel blockers commonly cause peripheral oedema. Spirinolactone is one of a numebr of causes of gynecomastia including oestrogen therapy, cannabis, chronic liver disease etc. Statins classically cause muscle cramps and in extreme cases rhabdomyolysis. Corticosteroids e.g. prednisolone have side effects including those listed along with fluid retention, weight gain, thin skin, hypertension etc.